Huaxiao “Adam” Yang

Assistant Professor
Discovery Park K240B
940-369-8959
Huaxiao.Yang@unt.edu
  • Education

    PhD, Bioengineering, 2015
    Department of Bioengineering, Clemson University
    Dissertation: Microfabricated environment for studying cardiomyocyte development, remodeling, and rescue

    MS, Macromolecular Chemistry and Physics, 2010
    Department of Macromolecular Science; Fudan University, China
    Thesis: Cardiovascular Tissue engineering applications of Biodegradable and biocompatible poly (3-hydroxybutyrate-co-3-hydroxyhexanoate)

    BS, Chemical Engineering, 2007
    Department of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, China

    BS, Biological Science, 2007
    Department of Biology, Wuhan University, China

  • Publications
    1. Kitchener D Wilson, Mohamed Ameen, Hongchao Guo, Oscar J Abilez, Lei Tian, Maxwell R Mumbach, Sebastian Diecke, Xulei Qin, Yonggang Liu, Huaxiao Yang, Ning Ma, Sadhana Gaddam, Nathan J Cunningham, Mingxia Gu, Evgenios Neofytou, Maricela Prado, Thomas B Hildebrandt, Ioannis Karakikes, Howard Y Chang, Joseph C Wu. Endogenous retrovirus-derived lncRNA BANCR promotes cardiomyocyte migration in humans and non-human primates. Developmental Cell, 2020
    2. Soah Lee,* Huaxiao Yang,* Caressa Chen,*, Sneha Venkatraman, Adrija Darsha, Sean M. Wu, Joseph C. Wu, Timon Seeger. Simple Lithography-Free Single Cell Micropatterning Technique Using Laser-Cut Stencils. *: co-first authors, Journal of Visualized Experiments, 2020
    3. Huaxiao Yang,* Xulei Qin, Huiyuan Wang, Xin Zhao, Yonggang Liu, Hung-Ta Wo, Chun Liu, Masataka Nishiga, Haodong Chen, Jing Ge, Nazish Sayed, Oscar J Abilez, Dan Ding, Sarah C Heilshorn, Kai Li.* An In Vivo miRNA Delivery System for Restoring Infarcted Myocardium. ACS Nano, *: co-corresponding authors, doi:10.1021/acsnano.9b03343, highlighted on the cover page, Perspective by Michael E. Davis (ACS Nano 2019, 13, 9, 9702-9706)
    4. Haodi Wu, Huaxiao Yang, June-Wha Rhee, Joe Z Zhang, Chi Keung Lam, Karim Sallam, Alex C Y Chang, Ning Ma, Jaecheol Lee, Hao Zhang, Helen M Blau, Donald M Bers, Joseph C Wu. Modelling diastolic dysfunction in induced pluripotent stem cell-derived cardiomyocytes from hypertrophic cardiomyopathy patients. European Heart Journal, doi:10.1093/eurheartj/ehz326, Introduced and discussed in Editorial (European Heart Journal, ehz447)
    5. Timon Seeger, Rajani Shrestha, Chi Keung Lam, Caressa Chen, Wesley L McKeithan, Edward Lau, Alexa Wnorowski, George McMullen, Matthew Greenhaw, Jaecheol Lee, Angelos Oikonomopoulos, Soah Lee, Huaxiao Yang, Mark Mercola, Matthew Wheeler, Euan A Ashley, Fan Yang, Ioannis Karakikes, Joseph C Wu. A premature termination codon mutation in MYBPC3 causes hypertrophic cardiomyopathy via chronic activation of nonsense-mediated decay. Circulation, 2019, 139 (6), 799-811
    6. Xin Zhao,* Haodong Chen,* Dan Xiao,* Huaxiao Yang, Ilanit Itzhaki, Xulei Qin, Tony Chour, Aitor Aguirre, Kim Lehmann, Youngkyun Kim, Praveen Shukla, Alexandra Holmström, Joe Z Zhang, Yan Zhuge, Babacar C Ndoye, Mingtao Zhao, Evgenios Neofytou, Wolfram-Hubertus Zimmermann, Mohit Jain, Joseph C Wu. Comparison of Non-human Primate versus Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Treatment of Myocardial Infarction. Stem cell reports, 2018, 10 (2), 422-435
    7. Oscar J Abilez,* Evangeline Tzatzalos,* Huaxiao Yang, Ming-Tao Zhao, Gwanghyun Jung, Alexander M Zöllner, Malte Tiburcy, Johannes Riegler, Elena Matsa, Praveen Shukla, Yan Zhuge, Tony Chour, Vincent C Chen, Paul W Burridge, Ioannis Karakikes, Ellen Kuhl, Daniel Bernstein, Larry A Couture, Joseph D Gold, Wolfram H Zimmermann, Joseph C Wu. Passive stretch induces structural and functional maturation of engineered heart muscle as predicted by computational modeling. Stem Cells, 2018, 36 (2), 265-277
    8. Kai Li, Carmel T Chan, Hossein Nejadnik, Olga D Lenkov, Cody Wolterman, Ramasamy Paulmurugan, Huaxiao Yang, Sanjiv Sam Gambhir, Heike E Daldrup-Link. Ferumoxytol-based Dual-modality Imaging Probe for Detection of Stem Cell Transplant Rejection. Nanotheranostics, 2018, 2 (4), 306
    9. Xulei Qin,* Haodong Chen,* Huaxiao Yang,* Haodi Wu, Xin Zhao, Huiyuan Wang, Tony Chour, Evgenios Neofytou, Dan Ding, Heike Daldrup‐Link, Sarah C Heilshorn, Kai Li, Joseph C Wu. Photoacoustic Imaging of Embryonic Stem Cell‐Derived Cardiomyocytes in Living Hearts with Ultrasensitive Semiconducting Polymer Nanoparticles. Advanced Functional Materials, 2018, 28 (1), 1704939, * co-first authors
    10. Ming-Tao Zhao, Haodong Chen, Qing Liu, Ning-Yi Shao, Nazish Sayed, Hung-Ta Wo, Joe Z Zhang, Sang-Ging Ong, Chun Liu, Youngkyun Kim, Huaxiao Yang, Tony Chour, Hong Ma, Nuria Marti Gutierrez, Ioannis Karakikes, Shoukhrat Mitalipov, Michael P Snyder, Joseph C Wu. Proceedings of the National Academy of Sciences, 2017, 114 (52), E11111-E11120
    11. Huaxiao Yang,* Lucas P Schmidt,* Zhonghai Wang,* Xiaoqi Yang, Yonghong Shao, Thomas K Borg, Roger Markwald, Raymond Runyan, Bruce Z Gao. Scientific reports, 2016, 6, 20674, * cofirst authors
    12. Huaxiao Yang, Thomas K Borg, Zhen Ma, Meifeng Xu, George Wetzel, Laxmikant V Saraf, Roger Markwald, Raymond B Runyan, Bruce Z Gao. Biofabrication, 2016, 8 (1), 015-012
    13. Huaxiao Yang, Thomas K Borg, Honghai Liu, Bruce Z Gao. Interactive relationship between basement-membrane development and sarcomerogenesis in single cardiomyocytes. Experimental cell research, 2015, 330 (1), 222-232
    14. Huaxiao Yang, Thomas K Borg, Lucas P Schmidt, Bruce Z Gao. Laser cell-micropatterned pair of cardiomyocytes: the relationship between basement membrane development and gap junction aturation. Biofabrication, 2014, 6 (4), 045003
    15. Honghai Liu, Ruikai Chen, Huaxiao Yang, Wan Qin, Thomas K Borg, Delphine Dean, Meifeng Xu, Bruce Z Gao. Enzyme-etching technique to fabricate micropatterns of aligned collagen fibrils. Biotechnology letters, 2014, 36 (6), 1245-1252
    16. Huaxiao Yang, Thomas K Borg, Zhonghai Wang, Zhen Ma, Bruce Z Gao. Role of the basement membrane in regulation of cardiac electrical properties. Annals of biomedical engineering, 2014, 42 (6), 1148-1157
    17. Zhen Ma, Qiuying Liu, Huaxiao Yang, Raymond B Runyan, Carol A Eisenberg, Meifeng Xu, Thomas K Borg, Roger Markwald, Yifei Wang, Bruce Z Gao. Laser patterning for the study of MSC cardiogenic differentiation at the single-cell level. Light: Science & Applications, 2013, 2 (5), e68
    18. Honghai Liu, Wan Qin, Yonghong Shao, Zhonghai Wang, Huaxiao Yang, Raymond B Runyan, Thomas K Borg, Bruce Gao. Disassembly of myofibrils in adult cardiomyocytes during dedifferentiation. Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues Xi, 2013, 8587(1W)
    19. Zhen Ma, Huaxiao Yang, Honghai Liu, Meifeng Xu, Raymond B Runyan, Carol A Eisenberg, Roger R Markwald, Thomas K Borg, Bruce Z Gao. Mesenchymal stem cell-cardiomyocyte interactions under defined contact modes on laser-patterned biochips. PLoS One, 2013, 8 (2), e56554
    20. Zhen Ma, Qiuying Liu, Honghai Liu, Huaxiao Yang, Julie X Yun, Meifeng Xu, Carol A Eisenberg, Thomas K Borg, Roger Markwald, Bruce Z Gao. Cardiogenic regulation of stem-cell electrical properties in a laser-patterned biochip. Cellular and molecular bioengineering, 2012, 5 (3), 327-336
    21. Zhen Ma, Qiuying Liu, Honghai Liu, Huaxiao Yang, Julie X Yun, Carol Eisenberg, Thomas K Borg, Meifeng Xu, Bruce Z Gao. Laser-patterned stem-cell bridges in a cardiac muscle model for on-chip electrical conductivity analyses. Lab on a Chip, 2012, 12 (3), 566-573 Curriculum Vitae Huaxiao ‘Adam’ Yang, Ph.D. Page 4
    22. Huaxiao Yang, Min Sun, Ping Zhou, Luanfeng Pan, Chungen Wu. Silk fibroins modify the atmospheric low temperature plasma-treated poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) film for the application of cardiovascular tissue engineering. Journal of Biomedical Science and Engineering, 2010, 3 (12), 1146
    23. Min Sun, Ping Zhou, Luan-Feng Pan, Shui Liu, Huaxiao Yang. Enhanced cell affinity of the silk fibroin-modified PHBHHx material. Journal of Materials Science: Materials in Medicine, 2009, 20 (8), 1743-1751
    24. Huaxiao Yang, Min Sun, Ping Zhou. Investigation of water diffusion in poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) by generalized two-dimensional correlation ATR–FTIR spectroscopy. Polymer, 2009, 50 (6), 1533-1540
  • Honors and Awards

    2018 – 2020 American Heart Association Postdoctoral Fellowship Award