- Education
PhD, Bioengineering, 2015
Department of Bioengineering, Clemson University
Dissertation: Microfabricated environment for studying cardiomyocyte development, remodeling, and rescueMS, Macromolecular Chemistry and Physics, 2010
Department of Macromolecular Science; Fudan University, China
Thesis: Cardiovascular Tissue engineering applications of Biodegradable and biocompatible poly (3-hydroxybutyrate-co-3-hydroxyhexanoate)BS, Chemical Engineering, 2007
Department of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, ChinaBS, Biological Science, 2007
Department of Biology, Wuhan University, China - Publications
- Kitchener D Wilson, Mohamed Ameen, Hongchao Guo, Oscar J Abilez, Lei Tian, Maxwell R Mumbach, Sebastian Diecke, Xulei Qin, Yonggang Liu, Huaxiao Yang, Ning Ma, Sadhana Gaddam, Nathan J Cunningham, Mingxia Gu, Evgenios Neofytou, Maricela Prado, Thomas B Hildebrandt, Ioannis Karakikes, Howard Y Chang, Joseph C Wu. Endogenous retrovirus-derived lncRNA BANCR promotes cardiomyocyte migration in humans and non-human primates. Developmental Cell, 2020
- Soah Lee,* Huaxiao Yang,* Caressa Chen,*, Sneha Venkatraman, Adrija Darsha, Sean M. Wu, Joseph C. Wu, Timon Seeger. Simple Lithography-Free Single Cell Micropatterning Technique Using Laser-Cut Stencils. *: co-first authors, Journal of Visualized Experiments, 2020
- Huaxiao Yang,* Xulei Qin, Huiyuan Wang, Xin Zhao, Yonggang Liu, Hung-Ta Wo, Chun Liu, Masataka Nishiga, Haodong Chen, Jing Ge, Nazish Sayed, Oscar J Abilez, Dan Ding, Sarah C Heilshorn, Kai Li.* An In Vivo miRNA Delivery System for Restoring Infarcted Myocardium. ACS Nano, *: co-corresponding authors, doi:10.1021/acsnano.9b03343, highlighted on the cover page, Perspective by Michael E. Davis (ACS Nano 2019, 13, 9, 9702-9706)
- Haodi Wu, Huaxiao Yang, June-Wha Rhee, Joe Z Zhang, Chi Keung Lam, Karim Sallam, Alex C Y Chang, Ning Ma, Jaecheol Lee, Hao Zhang, Helen M Blau, Donald M Bers, Joseph C Wu. Modelling diastolic dysfunction in induced pluripotent stem cell-derived cardiomyocytes from hypertrophic cardiomyopathy patients. European Heart Journal, doi:10.1093/eurheartj/ehz326, Introduced and discussed in Editorial (European Heart Journal, ehz447)
- Timon Seeger, Rajani Shrestha, Chi Keung Lam, Caressa Chen, Wesley L McKeithan, Edward Lau, Alexa Wnorowski, George McMullen, Matthew Greenhaw, Jaecheol Lee, Angelos Oikonomopoulos, Soah Lee, Huaxiao Yang, Mark Mercola, Matthew Wheeler, Euan A Ashley, Fan Yang, Ioannis Karakikes, Joseph C Wu. A premature termination codon mutation in MYBPC3 causes hypertrophic cardiomyopathy via chronic activation of nonsense-mediated decay. Circulation, 2019, 139 (6), 799-811
- Xin Zhao,* Haodong Chen,* Dan Xiao,* Huaxiao Yang, Ilanit Itzhaki, Xulei Qin, Tony Chour, Aitor Aguirre, Kim Lehmann, Youngkyun Kim, Praveen Shukla, Alexandra Holmström, Joe Z Zhang, Yan Zhuge, Babacar C Ndoye, Mingtao Zhao, Evgenios Neofytou, Wolfram-Hubertus Zimmermann, Mohit Jain, Joseph C Wu. Comparison of Non-human Primate versus Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Treatment of Myocardial Infarction. Stem cell reports, 2018, 10 (2), 422-435
- Oscar J Abilez,* Evangeline Tzatzalos,* Huaxiao Yang, Ming-Tao Zhao, Gwanghyun Jung, Alexander M Zöllner, Malte Tiburcy, Johannes Riegler, Elena Matsa, Praveen Shukla, Yan Zhuge, Tony Chour, Vincent C Chen, Paul W Burridge, Ioannis Karakikes, Ellen Kuhl, Daniel Bernstein, Larry A Couture, Joseph D Gold, Wolfram H Zimmermann, Joseph C Wu. Passive stretch induces structural and functional maturation of engineered heart muscle as predicted by computational modeling. Stem Cells, 2018, 36 (2), 265-277
- Kai Li, Carmel T Chan, Hossein Nejadnik, Olga D Lenkov, Cody Wolterman, Ramasamy Paulmurugan, Huaxiao Yang, Sanjiv Sam Gambhir, Heike E Daldrup-Link. Ferumoxytol-based Dual-modality Imaging Probe for Detection of Stem Cell Transplant Rejection. Nanotheranostics, 2018, 2 (4), 306
- Xulei Qin,* Haodong Chen,* Huaxiao Yang,* Haodi Wu, Xin Zhao, Huiyuan Wang, Tony Chour, Evgenios Neofytou, Dan Ding, Heike Daldrup‐Link, Sarah C Heilshorn, Kai Li, Joseph C Wu. Photoacoustic Imaging of Embryonic Stem Cell‐Derived Cardiomyocytes in Living Hearts with Ultrasensitive Semiconducting Polymer Nanoparticles. Advanced Functional Materials, 2018, 28 (1), 1704939, * co-first authors
- Ming-Tao Zhao, Haodong Chen, Qing Liu, Ning-Yi Shao, Nazish Sayed, Hung-Ta Wo, Joe Z Zhang, Sang-Ging Ong, Chun Liu, Youngkyun Kim, Huaxiao Yang, Tony Chour, Hong Ma, Nuria Marti Gutierrez, Ioannis Karakikes, Shoukhrat Mitalipov, Michael P Snyder, Joseph C Wu. Proceedings of the National Academy of Sciences, 2017, 114 (52), E11111-E11120
- Huaxiao Yang,* Lucas P Schmidt,* Zhonghai Wang,* Xiaoqi Yang, Yonghong Shao, Thomas K Borg, Roger Markwald, Raymond Runyan, Bruce Z Gao. Scientific reports, 2016, 6, 20674, * cofirst authors
- Huaxiao Yang, Thomas K Borg, Zhen Ma, Meifeng Xu, George Wetzel, Laxmikant V Saraf, Roger Markwald, Raymond B Runyan, Bruce Z Gao. Biofabrication, 2016, 8 (1), 015-012
- Huaxiao Yang, Thomas K Borg, Honghai Liu, Bruce Z Gao. Interactive relationship between basement-membrane development and sarcomerogenesis in single cardiomyocytes. Experimental cell research, 2015, 330 (1), 222-232
- Huaxiao Yang, Thomas K Borg, Lucas P Schmidt, Bruce Z Gao. Laser cell-micropatterned pair of cardiomyocytes: the relationship between basement membrane development and gap junction aturation. Biofabrication, 2014, 6 (4), 045003
- Honghai Liu, Ruikai Chen, Huaxiao Yang, Wan Qin, Thomas K Borg, Delphine Dean, Meifeng Xu, Bruce Z Gao. Enzyme-etching technique to fabricate micropatterns of aligned collagen fibrils. Biotechnology letters, 2014, 36 (6), 1245-1252
- Huaxiao Yang, Thomas K Borg, Zhonghai Wang, Zhen Ma, Bruce Z Gao. Role of the basement membrane in regulation of cardiac electrical properties. Annals of biomedical engineering, 2014, 42 (6), 1148-1157
- Zhen Ma, Qiuying Liu, Huaxiao Yang, Raymond B Runyan, Carol A Eisenberg, Meifeng Xu, Thomas K Borg, Roger Markwald, Yifei Wang, Bruce Z Gao. Laser patterning for the study of MSC cardiogenic differentiation at the single-cell level. Light: Science & Applications, 2013, 2 (5), e68
- Honghai Liu, Wan Qin, Yonghong Shao, Zhonghai Wang, Huaxiao Yang, Raymond B Runyan, Thomas K Borg, Bruce Gao. Disassembly of myofibrils in adult cardiomyocytes during dedifferentiation. Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues Xi, 2013, 8587(1W)
- Zhen Ma, Huaxiao Yang, Honghai Liu, Meifeng Xu, Raymond B Runyan, Carol A Eisenberg, Roger R Markwald, Thomas K Borg, Bruce Z Gao. Mesenchymal stem cell-cardiomyocyte interactions under defined contact modes on laser-patterned biochips. PLoS One, 2013, 8 (2), e56554
- Zhen Ma, Qiuying Liu, Honghai Liu, Huaxiao Yang, Julie X Yun, Meifeng Xu, Carol A Eisenberg, Thomas K Borg, Roger Markwald, Bruce Z Gao. Cardiogenic regulation of stem-cell electrical properties in a laser-patterned biochip. Cellular and molecular bioengineering, 2012, 5 (3), 327-336
- Zhen Ma, Qiuying Liu, Honghai Liu, Huaxiao Yang, Julie X Yun, Carol Eisenberg, Thomas K Borg, Meifeng Xu, Bruce Z Gao. Laser-patterned stem-cell bridges in a cardiac muscle model for on-chip electrical conductivity analyses. Lab on a Chip, 2012, 12 (3), 566-573 Curriculum Vitae Huaxiao ‘Adam’ Yang, Ph.D. Page 4
- Huaxiao Yang, Min Sun, Ping Zhou, Luanfeng Pan, Chungen Wu. Silk fibroins modify the atmospheric low temperature plasma-treated poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) film for the application of cardiovascular tissue engineering. Journal of Biomedical Science and Engineering, 2010, 3 (12), 1146
- Min Sun, Ping Zhou, Luan-Feng Pan, Shui Liu, Huaxiao Yang. Enhanced cell affinity of the silk fibroin-modified PHBHHx material. Journal of Materials Science: Materials in Medicine, 2009, 20 (8), 1743-1751
- Huaxiao Yang, Min Sun, Ping Zhou. Investigation of water diffusion in poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) by generalized two-dimensional correlation ATR–FTIR spectroscopy. Polymer, 2009, 50 (6), 1533-1540
- Honors and Awards
2018 – 2020 American Heart Association Postdoctoral Fellowship Award