- Education
Ph.D. in Biological Chemistry, 2011
Department of Chemistry, Massachusetts Institute of Technology
Thesis: A systems-level analysis of dynamic reprogramming of RNA modifications in the translational control of cellular responsesB.S. in Chemistry, 2005
The University of Wisconsin-MadisonB.S. in Biochemistry, 2005
The University of Wisconsin-Madison - Publications
- Dimas, R.P.*, Jordoan, B.R.*, Jiang, X., Martini, C., Glavy, J.S., Patterson, D.P., Morcos, F., and Chan, C.T.Y. (2019). Engineering DNA recognition and allosteric response properties of TetR family proteins by using a module-swapping strategy. Nucleic Acids Research. 47(16):8913-8925. DOI: 10.1093/nar/gkz666.
- Dimas, R.P.*, Jiang, X.*, Alberto de la Paz, J., Morcos, F., and Chan, C.T.Y. (2019). Engineering repressors with coevolutionary cues facilitates toggle switches with a master reset. Nucleic Acids Research. 47(10):5449-5463. DOI: 10.1093/nar/gkz280.
- Lee, J.W.*, Chan, C.T.Y.*, Slomovic, S., Collins, J.J. (2018). Next-generation biocontainment systems for engineered organisms. Nature Chemical Biology. 14:530-537.
- Chan, C.T.Y.*, Lee, J.W.*, Cameron, D.E.*, Bashor, C.J., and Collins, J.J. (2016). “Deadman” and “passcode” microbial kill switches for bacterial containment. Nature Chemical Biology. 12(2):82-86.
- Highlighted in Nature. 528(7581):166-167. Kill switches limit modified microbes. Sutter, P. (2015).
- Highlighted in Science. 351(6272):462-463. Engineering a bacterial “Deadman” walking. Vinson, V. (2016).
- Highlighted in Nature Review Genetics. 17(2):67. Synthetic biology: Genetic kill switches – a matter of life or death. Osorio, J. (2016).
- Highlighted in Chemical & Engineering News, Top Research of 2015. Keeping GMOs on a leash. Everts, S. (2015).
- Accompanying News & Views article in Nature Chemical Biology. 12(2):55-56. Building genetic containment. Haynes, K.A. (2016).
- Chan, C.T.Y.*, Deng, W.*, Li, F., DeMott, M.S., Babu, I.R., Begley, T.J., and Dedon, P.C. (2015). Highly predictive reprogramming of tRNA modifications is linked to selective expression of codon-biased genes. Chemical Research in Toxicology. 28(5):978-988.
- Dwyer, D.J., Belenky, P.A., Yang, J.H., MacDonald, I.C., Martell, J.D., Takahashi, N., Chan, C.T.Y., Lobritz, M.A., Braff, D., Schwarz, E.G., Ye, J.D., Pati, M., Vercruysse, M., Ralifo, P.S., Allison, K.R., Khalil, A.S., Ting, A.Y., Walker, G.C., and Collins, J.J. (2014). Antibiotics induce redox-related physiological alterations as part of their lethality. Proceedings of the National Academy of Sciences of the U.S.A. 111(20):E2100-E2109.
- Su, D., Chan, C.T.Y., Gu, C., Lim, K.S., Chionh, Y.H., McBee, M.E., Russell, B.S., Babu, I.R., Begley, T.J., and Dedon, P.C. (2014). Quantitative analysis of ribonucleoside modifications in tRNA by HPLC-coupled mass spectrometry. Nature Protocols. 9(4):828-841.
- Mandal, D., Köhrer, C. Su, D., Babu, I.R., Chan, C.T.Y., Liu, Y., Söll, D., Blum, P., Kuwahara, M., Dedon, P.C., and Rajbhandary, U.L. (2014). Identification and codon reading properties of 5-cyanomethyl uridine, a new modified nucleoside found in the anticodon wobble position of mutant haloarchaeal isoleucine tRNAs. RNA. 20(2):177-188.
- Begley, J., Sosa, M.S., Avivar-Valderas, A., Patil, A., Endres, L., Estrada, Y., Chan, C.T.Y., Su, D., Dedon, P.C., Aguirre-Ghiso, J.A., and Begley, T.J. (2013). A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α. EMBO Molecular Medicine. 5(3):366-383.
- Patil, A., Dyavaiah, M., Joseph, F., Rooney, J.P., Chan, C.T.Y., Dedon P.C., and Begley, T.J. (2012). Increased tRNA modification and gene-specific codon usage regulate cell cycle progression during the DNA damage response. Cell Cycle. 11(19):3656-3665.
- Patil, A., Chan, C.T.Y., Dyavaiah, M., Rooney, J.P., Dedon, P.C., and Begley, T.J. (2012). Translational infidelity-induced protein stress results from a deficiency in Trm9-catalyzed tRNA modifications. RNA Biology. 9(7):990-1001.
- Chan, C.T.Y., Pang, Y.L., Deng, W., Babu, I.R., Dyavaiah, M., Begley, T.J., and Dedon, P.C. (2012). Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins. Nature Communications. 3:937.
- Chan, C.T.Y., Chionh, Y.H., Ho, C, Lim, K.S., Babu, I.R., Ang, E., Lin, W., Alonso, S., and Dedon P.C. (2011). Identification of N6,N6-dimethyladenosine in transfer RNA from Mycobacterium bovis Bacille Calmette-Guérin. Molecules. 16(6):5168-5181.
- Chan C.T.Y., Dyavaiah M., DeMott M.S., Taghizadeh K., Dedon P.C., and Begley T.J. (2010). A quantitative systems approach reveals dynamic control of tRNA modifications during cellular stress. PLoS Genetics. 6(12):e1001247.
- Highlighted in Nature Methods. 8(2):108-109. Better living through biochemistry. Eisenstein, M. (2011).
- Highlighted in Nature Review Genetics. 12(2):77. In brief: translational control – a quantitative systems approach reveals dynamic control of tRNA modifications during cellular stress. Muers, M. (2012).
- Fu, D., Brophy J.A., Chan, C.T.Y., Atmore, K.A., Begley, U., Paules, R.S., Dedon, P.C., Begley, T.J., and Samson, L.D. (2010). Human AlkB homolog ABH8 is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival. Molecular and Cellular Biology. 30(10):2449-2459.
- Seyedsayamdost, M.R., Chan, C.T.Y., Mugnaini, V., Stubbe, J. and Bennati, M. (2007). PELDOR spectroscopy with DOPA−α2 and NH2Y−β2: distance measurements between residues involved in the radical propagation pathway of E. coli ribonucleotide reductase. Journal of American Chemical Society. 129:15748-15749.
- Seyedsayamdost, M.R., Xie, J., Chan, C.T.Y., Schultz, P.G., and Stubbe, J. (2007). Site-specific insertion of 3-aminotyrosine into subunit α2 of E. coli ribonucleotide reductase: direct evidence for involvement of Y730 and Y731 in radical propagation. Journal of American Chemical Society. 129:15060-15071.
- Patents
- Chan, T.Y.C., Collins, J.J., Lee, J.W., and Cameron, D.E. (2017) Deadman and passcode microbial kill switches. Patent publication number WO 2017/059245 A3.
- Seyedsayamdost, M.R., Xie, J., Chan, C.T.Y., Alfonta, L., Schultz, P.G., and Stubbe, J. (2014). Genetic incorporation of 3-aminotyrosine into reductases. Patent publication number US8673591 B2.
- Honors and Awards
2018-2019
Teaching and Learning Award
Center for Excellence in Teaching and Learning, UT Tyler